von Yi Zhong ; Yanguang Liu ; Hu Yang ; Qiuzhen Yin ; David J. Wilson ; Zhengyao Lu ; Samuel L. Jaccard ; Torben Struve ; P. D. Clift ; Stefanie Kaboth-Bahr ; Juan C. Larrasoaña ; André Bahr ; Xun Gong ; Debo Zhao ; Yanan Zhang ; Wenyue Xia ; Qingsong Liu
Airborne mineral dust is sensitive to climatic changes, but its response to orbital forcing is still not fully understood. Here, we present a reconstruction of dust input to the Subarctic Pacific Ocean covering the past 190 kyr. The dust composition record is indicative of source moisture conditions, which were dominated by precessional variations. In contrast, the dust flux record is dominated by obliquity variations and displays an out-of-phase relationship with a dust record from the mid-latitude North Pacific Ocean. Climate model simulations suggest precession likely drove changes in the aridity and extent of dust source regions. Additionally, the obliquity variations in dust flux can be explained by meridional shifts in the North Pacific westerly jet, driven by changes in the meridional atmospheric temperature gradient. Overall, our findings suggest that North Pacific dust input was primarily modulated by orbital-controlled source aridity and the strength and position of the westerly winds.
Geophysical research letters Hoboken, NJ : Wiley, 1974 51(2024), 4, Artikel-ID e2023GL106631, Seite 2023GL106631-1-e2023GL106631-14 Online-Ressource
Neurostimulation is a mainstream treatment option for major depression. Neuromodulation techniques apply repetitive magnetic or electrical stimulation to some neural target but significantly differ in their invasiveness, spatial selectivity, mechanism of action, and efficacy. Despite these differences, recent analyses of transcranial magnetic stimulation (TMS) and deep brain stimulation (DBS)-treated individuals converged on a common neural network that might have a causal role in treatment response. We set out to investigate if the neuronal underpinnings of electroconvulsive therapy (ECT) are similarly associated with this causal depression network (CDN). Our aim here is to provide a comprehensive analysis in three cohorts of patients segregated by electrode placement (N = 246 with right unilateral, 79 with bitemporal, and 61 with mixed) who underwent ECT. We conducted a data-driven, unsupervised multivariate neuroimaging analysis Principal Component Analysis (PCA) of the cortical and subcortical volume changes and electric field (EF) distribution to explore changes within the CDN associated with antidepressant outcomes. Despite the different treatment modalities (ECT vs TMS and DBS) and methodological approaches (structural vs functional networks), we found a highly similar pattern of change within the CDN in the three cohorts of patients (spatial similarity across 85 regions: r = 0.65, 0.58, 0.40, df = 83). Most importantly, the expression of this pattern correlated with clinical outcomes (t = −2.35, p = 0.019). This evidence further supports that treatment interventions converge on a CDN in depression. Optimizing modulation of this network could serve to improve the outcome of neurostimulation in depression.
von Martin Benedikt ; Eckard Böde ; Andreas Bossert ; Jens Braband ; Tino Brade ; Niklas Braun ; Tobias Braun ; Simon Burton ; Thomas Dallmann ; Werner Damm ; Tobias Düser ; Lukas Elster ; Tim Fingscheidt ; Marco Fistler ; Marzena Franek ; Martin Fränzle ; Jonas Freyer ; Roland Galbas ; Roman Gansch ; Dirk Geyer ; Lukas Haas ; Arsalan Haider ; Peter Heidl ; Matthias Hein ; Andreas Heyl ; Johannes Hiller ; Hardi Hungar ; Dieter Hutter ; Rolf Jung ; Cornel Klein ; Jörg Krüger ; Thomas Kuhn ; Jacob Langner ; Markus Maurer ; Kerstin Mayr ; André Meyer-Vitali ; Eike Möhlmann ; Adam Molin ; Björn Möller ; Jürgen Niehaus ; Bastian Nolte ; Marcus Nolte ; Stefan Otten ; Jan Peleska ; Steven Peters ; Tim Poguntke ; Florian Poprawa ; Jan Reich ; Philipp Rosenberger ; Nayel Fabian Salem ; Bernhard Schick ; Daniel Schneider ; Stefan-Alexander Schneider ; Christian Schyr ; Carsten Thomas ; Mario Trapp ; Florence Wagner ; Nicolas Wagener ; Timo Woopen ; Thomas Zeh
von Yi Zhong ; Ning Tan ; Jordan T. Abell ; Chijun Sun ; Stefanie Kaboth-Bahr ; Heather L. Ford ; Timothy D. Herbert ; Alex Pullen ; Keiji Horikawa ; Jimin Yu ; Torben Struve ; Michael E. Weber ; P. D. Clift ; Juan C. Larrasoaña ; Zhengyao Lu ; Hu Yang ; André Bahr ; Tianyu Chen ; Jingyu Zhang ; Cao Wei ; Wenyue Xia ; Sheng Yang ; Qingsong Liu
The Transformation of Consumer Law and Policy in Europe 1st ed [Erscheinungsort nicht ermittelbar] : Hart Publishing, 2023 (2023), Seite 261-280 1 Online-Ressource (376 pages)
Seite 8 von 294
