von Martin Baunacke ; Maria-Luisa Schmidt ; Christer Groeben ; Angelika Sabina Maria Borkowetz ; Christian Thomas ; Rainer Koch ; Falk Hoffmann ; Felix Chun ; Lothar Weißbach ; Johannes Huber
von Marc René Lotz ; Neelotpal Majumdar ; Vanessa Beutel ; Jana Gerlach ; Carsten Wegkamp ; Melanie Hoffmann ; Lily Kahl ; Jonas Wussow ; Henning Schlachter ; Carsten Agert ; Michael H. Breitner ; Bernd Engel ; Stefan Ewald Geißendörfer ; Lutz Hofmann ; Martin Könemund ; Michael Kurrat ; Thomas Leveringhaus ; Karsten von Maydell
NEIS Conference on Sustainable Energy Supply and Energy Storage Systems (9. : 2021 : Online) NEIS 2021 Berlin : VDE Verlag, 2021 (2021), Seite 53-60 1 Online-Ressource
von Timo Stöver ; Stefan Dazert ; Stefan K.-R. Plontke ; Sabine Maria Kramer ; Petra Ambrosch ; Christoph Arens ; Christian Stephan Betz ; Dirk Beutner ; Christopher Bohr ; Karl-Ludwig Bruchhage ; Martin Canis ; Andreas Dietz ; Orlando Guntinas-Lichius ; Rudolf Hagen ; Werner Hosemann ; Heinrich Iro ; Jens Peter Klußmann ; Andreas Knopf ; Stephan Lang ; Martin Leinung ; Thomas Lenarz ; Hubert Martin Löwenheim ; Christoph Matthias ; Robert Arndt Mlynski ; Heidi Olze ; Jonas Jae-Hyun Park ; Peter K. Plinkert ; Andreas Daniel Radeloff ; Nicole Rotter ; Claudia Rudack ; Alessandro Bozzato ; Jörg H. Schipper ; Martin Schrader ; Patrick Schuler ; Sebastian Strieth ; Boris Stuck ; Stefan Volkenstein ; Martin Westhofen ; Gregor Wolf ; Barbara Wollenberg ; Thomas Zahnert ; Johannes Zenk ; Thomas K. Hoffmann
von Ulrike Mütze ; Lucy Henze ; Florian Gleich ; Martin Lindner ; Sarah C. Grünert ; Ute Spiekerkoetter ; René Santer ; Holger Blessing ; Eva Thimm ; Regina Ensenauer ; Johannes Weigel ; Skadi Beblo ; Maria Arélin ; Julia B. Hennermann ; Thorsten Marquardt ; Iris Marquardt ; Peter Freisinger ; Johannes Krämer ; Andrea Dieckmann ; Natalie Weinhold ; Mareike Keller ; Magdalena Walter ; Katharina A. Schiergens ; Esther M. Maier ; Georg F. Hoffmann ; Sven F. Garbade ; Stefan Kölker
von Jonas Wussow ; Davood Babazadeh ; Vanessa Beutel ; Sebastian Buchholz ; Stefan Ewald Geißendörfer ; Jana Gerlach ; Neelopal Majumdar ; Karsten von Maydell ; Anand Narayan ; Melanie Hoffmann ; Lily Kahl ; Thomas Leveringhaus ; Marc Rene Lotz ; Alexandra Scheunert ; Payam Teimourzadeh Baboli ; Paul Hendrik Tiemann ; Nils Huxoll ; Oliver Werth ; Carsten Agert ; Michael H. Breitner ; Bernd Engel ; Lutz Hofmann ; Martin Könemund ; Michael Kurrat ; Sebastian Lehnhoff ; Astrid Nieße ; Hartmut Weyer
von Robert Templin ; Navid Tabriz ; Martin Hoffmann ; Verena-Nicole Uslar ; Thomas Lück ; Andrea Schenk ; Rainer Malaka ; Gabriel Zachmann ; Alexander Kluge ; Dirk Alfons Weyhe
American journal of physical medicine & rehabilitation Baltimore, Md. : Lippincott Williams & Wilkins, 1952 99(2020), 6, Seite 532-539 Online-Ressource
von Timo Stöver ; Stefan Dazert ; Thomas K. Hoffmann ; Stefan K.-R. Plontke ; Petra Ambrosch ; Christoph Arens ; Christian Stephan Betz ; Dirk Beutner ; Christopher Bohr ; Karl-Ludwig Bruchhage ; Martin Canis ; Andreas Dietz ; Orlando Guntinas-Lichius ; Rudolf Hagen ; Werner Hosemann ; Heinrich Iro ; Jens Peter Klußmann ; Andreas Knopf ; Sabine Maria Kramer ; Stephan Lang ; Martin Leinung ; Thomas Lenarz ; Hubert Martin Löwenheim ; Christoph Matthias ; Robert Arndt Mlynski ; Heidi Olze ; Jonas Jae-Hyun Park ; Peter K. Plinkert ; Andreas Daniel Radeloff ; Nicole Rotter ; Claudia Rudack ; Alessandro Bozzato ; Jörg H. Schipper ; Martin Schrader ; Sebastian Strieth ; Boris Stuck ; Stefan Volkenstein ; Martin Westhofen ; Gregor Wolf ; Barbara Wollenberg ; Thomas Zahnert ; Johannes Zenk
von Bernhard Wörmann ; Carsten Bokemeyer ; Thomas Burmeister ; Claus-Henning Köhne ; Matthias Schwab ; Dirk Arnold ; Jens-Uwe Blohmer ; Markus Borner ; Sara Brucker ; Ingolf Cascorbi ; Thomas Decker ; Maike de Wit ; Andreas Dietz ; Hermann Einsele ; Wolfgang Eisterer ; Gunnar Folprecht ; Wolfgang Hilbe ; Jürgen Hoffmann ; Wolfgang Knauf ; Volker Kunzmann ; Carlo R. Largiadèr ; Sylvie Lorenzen ; Diana Lüftner ; Markus Moehler ; Markus M. Nöthen ; Christian Pox ; Anke Reinacher-Schick ; Anton Scharl ; Brigitte Schlegelberger ; Thomas Seufferlein ; Marianne Sinn ; Matthias Stroth ; Ingo Tamm ; Lorenz Trümper ; Martin Wilhelm ; Ewald Wöll ; Ralf-Dieter Hofheinz
<b><i>Background:</i></b> 5-Fluorouracil (FU) is one of the most commonly used cytostatic drugs in the systemic treatment of cancer. Treatment with FU may cause severe or life-threatening side effects and the treatment-related mortality rate is 0.2-1.0%. <b><i>Summary:</i></b> Among other risk factors associated with increased toxicity, a genetic deficiency in dihydropyrimidine dehydrogenase (DPD), an enzyme responsible for the metabolism of FU, is well known. This is due to variants in the DPD gene (<i>DPYD</i>). Up to 9% of European patients carry a DPD gene variant that decreases enzyme activity, and DPD is completely lacking in approximately 0.5% of patients. Here we describe the clinical and genetic background and summarize recommendations for the genetic testing and tailoring of treatment with 5-FU derivatives. The statement was developed as a consensus statement organized by the German Society for Hematology and Medical Oncology in cooperation with 13 medical associations from Austria, Germany, and Switzerland. <b><i>Key Messages:</i></b> (i) Patients should be tested for the 4 most common genetic <i>DPYD</i> variants before treatment with drugs containing FU. (ii) Testing forms the basis for a differentiated, risk-adapted algorithm with recommendations for treatment with FU-containing drugs. (iii) Testing may optionally be supplemented by therapeutic drug monitoring.
Oncology research and treatment Basel : Karger, 2014 43(2020), 11, Seite 628-636 Online-Ressource
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