International journal of environmental research and public health Basel : MDPI AG, 2004 Volume 17 (2020), 19, article 7126, Seite 1-10 Online-Ressource
Objectives - On the basis of current treatment guidelines, we developed and validated a medication-based chronic disease score (medCDS) and tested its association with all-cause mortality of older outpatients. - Study Design and Setting - Considering the most prevalent chronic diseases in the elderly German population, we compiled a list of evidence-based medicines used to treat these disorders. Based on this list, a score (medCDS) was developed to predict mortality using data of a large longitudinal cohort of older outpatients (training sample; MultiCare Cohort Study). By assessing receiver-operating characteristics (ROC) curves, the performance of medCDS was then confirmed in independent cohorts (ESTHER, KORA-Age) of community-dwelling older patients and compared with already existing medication-based scores and a score using selected anatomical-therapeutic-chemical (ATC) codes. - Results - The final medCDS score had an ROC area under the curve (AUC) of 0.73 (95% CI 0.70-0.76). In the validation cohorts, its ROC AUCs were 0.79 (0.76-0.82, KORA-Age) and 0.74 (0.71-0.78, ESTHER), which were superior to already existing medication-based scores (RxRisk, CDS) and scores based on pharmacological ATC code subgroups (ATC3) or age and sex alone (Age&Sex). - Conclusions - A new medCDS, which is based on actual treatment standards, predicts mortality of older outpatients significantly better than already existing scores.
Journal of clinical epidemiology Amsterdam [u.a.] : Elsevier Science, 1988 105(2019), Seite 112-124 Online-Ressource
von Gabriel Torbahn ; Heidelore Hofmann ; Gerta Rücker ; Karin Bischoff ; Michael H. Freitag ; Rick Dersch ; Volker Fingerle ; Edith Motschall ; Jörg J. Meerpohl ; Christine Schmucker
Deutsche Gesellschaft für Medizinische Dokumentation, Informatik und Statistik German medical data sciences Amsterdam : IOS Press, 2017 (2017), Seite 65-69 1 Online-Ressource