von Jan Alexander Stratmann ; Sebastian Michels ; Sofia Emily Tsion Hornetz ; Daniel C. Christoph ; Sandra Sackmann ; Werner Spengle ; Helge Bischoff ; Monica Schäfer ; Jürgen Alt ; Annette Müller ; Eckart Laack ; Martin Kimmich ; Frank Griesinger ; Martin Sebastian
von Dennis Plenker ; Miriam Bertrand ; Adrianus J. de Langen ; Richard Riedel ; Carina Lorenz ; Andreas Scheel ; Judith Müller ; Johannes Brägelmann ; Juliane Daßler-Plenker ; Carsten Andreas Kobe ; Thorsten Persigehl ; Alexander Kluge ; Thomas Wurdinger ; Pepijn Schellen ; Gunther Hartmann ; Tobias Zacherle ; Roopika Menon ; Erik Thunnissen ; Reinhard Büttner ; Frank Griesinger ; Jürgen Wolf ; Lukas Heukamp ; Martin Lukas Sos ; Johannes M. Heuckmann
von T.S. Mok ; Y.-L. Wu ; M.C. Garassino ; H.R. Kim ; S.S. Ramalingam ; F.A. Shepherd ; Y. He ; H. Akamatsu ; W.S.M.E. Theelen ; C.K. Lee ; M. Sebastian ; H. Templeton ; H. Mann ; M. Marotti ; S. Ghiorghiu ; V.A. Papadimitrakopoulou ; Frank Griesinger
von Judith N. Müller ; Markus Falk ; Jatin Talwar ; Nicole Neemann ; Erika Mariotti ; Miriam Bertrand ; Tobias Zacherle ; Sotirios Lakis ; Roopika Menon ; Christian Gloeckner ; Markus Tiemann ; Lukas C. Heukamp ; Roman K. Thomas ; Frank Griesinger ; Johannes M. Heuckmann
von Maximilian von Laffert ; Peter Schirmacher ; Arne Warth ; W. Weichert ; R. Büttner ; R. M. Huber ; J. Wolf ; Frank Griesinger ; M. Dietel ; C. Grohé
The EML4-ALK pathway plays an important role in a significant subset of non-small cell lung cancer patients. Treatment options such as ALK tyrosine kinase inhibitors lead to improved progression free survival and overall survival. These therapeutic options are chosen on the basis of the identification of the underlying genetic signature of the EML-ALK translocation. Efficient and easily accessible testing tools are required to identify eligible patients in a timely fashion. While FISH techniques are commonly used to detect this translocation, the broad implementation of this type of ALK testing into routine diagnostics is not optimal due to technical, structural and financial reasons. Immunohistochemical techniques to screen for EML4-ALK translocations may therefore play an important role in the near future. This consensus paper provides recommendations for the test algorithm and quality of the respective test approaches, which are discussed in the light of the current literature.
Lung cancer Amsterdam [u.a.] : Elsevier, 1985 103(2017), Seite 1-5 Online-Ressource
von Ulrich Herrlinger ; Niklas Schäfer ; Rolf Fimmers ; Frank Griesinger ; Michael Rauch ; Heinz Kirchen ; Patrick Roth ; Martin Glas ; Michael Bamberg ; Peter Martus ; Eckhard Thiel ; Agnieszka Korfel ; Michael Weller