von Clemens Eckel ; Won-Keun Kim ; Dagmar Sötemann ; Christina Grothusen ; Vedat Tiyerili ; Guido Dohmen ; Matthias Renker ; Efstratios I. Charitos ; Christian W. Hamm ; Yeong-Hoon Choi ; Albrecht Elsässer ; Helge Möllmann ; Johannes Blumenstein
von Clemens Enno Eckel ; Won-Keun Kim ; Judith Schlüter ; Matthias Renker ; Sophie Bargon ; Christina Grothusen ; Albrecht Elsässer ; Guido Dohmen ; Yeong-Hoon Choi ; Efstratios I. Charitos ; Christian W. Hamm ; Samuel Sossalla ; Helge Möllmann ; Johannes Blumenstein
Erstmals online veröffentlicht: 15. Mai 2024 ; Gesehen am 17.12.2024
Aim - Out-of-hospital cardiac arrest (OHCA) is a major health concern in Western societies. Poor outcome after OHCA is determined by the extent of hypoxic-ischemic encephalopathy (HIE). Dysregulation of iron metabolism has prognostic relevance in patients with ischemic stroke and sepsis. The aim of this study was to determine whether serum iron parameters help to estimate outcomes after OHCA. - Methods - In this prospective single-center study, 70 adult OHCA patients were analyzed. Serum ferritin, iron, transferrin (TRF), and TRF saturation (TRFS) were measured in blood samples drawn on day 0 (admission), day 2, day 4, and 6 months after the return of spontaneous circulation (ROSC). The association of 4 iron parameters with in-hospital mortality, neurological outcome (cerebral performance category [CPC]), and HIE was investigated by receiver operating characteristics and multivariate regression analyses. - Results - OHCA subjects displayed significantly increased serum ferritin levels on day 0 and lowered iron, TRF, and TRFS on days 2 and 4 after ROSC, as compared to concentrations measured at a 6-month follow-up. Iron parameters were not associated with in-hospital mortality or neurological outcomes according to the CPC. Ferritin on admission was an independent predictor of features of HIE on cranial computed tomography and death due to HIE. - Conclusion - OHCA is associated with alterations in iron metabolism that persist for several days after ROSC. Ferritin on admission can help to predict HIE.
Journal of intensive care medicine Thousand Oaks, Calif. [u.a.] : Sage Science Press, 1986 39(2024), 11 vom: Nov., Seite 1120-1130 Online-Ressource
von Clemens Enno Eckel ; Won-Keun Kim ; Botros Wasif ; Christina Grothusen ; Albrecht Elsässer ; Guido Dohmen ; Efstratios I. Charitos ; Samuel Tobias Sossalla ; Helge Möllmann ; Johannes Blumenstein
von Bastian Schrader ; Charisa Conradi ; Stephan Lüders ; Bernhardt Vaske ; Matin Koziolek ; Eugen Gehlenborg ; Hermann Haller ; Albrecht Elsässer ; Joachim Schrader
von Clemens Enno Eckel ; Johannes Blumenstein ; Christina Grothusen ; Vedat Tiyerili ; Albrecht Elsässer ; Guido Dohmen ; Anna Zeckzer ; Luise Gaede ; Yeong-Hoon Choi ; Efstratios I. Charitos ; Christian Hamm ; Won-Keun Kim ; Helge Möllmann ; Matthias Renker
