von Mylena D. Bos ; Niels Helge Meyer ; Allard G. Wijma ; Karl Khatib-Chahidi ; Evert van den Broek ; Cassandra S. L. Ho ; Mark Meerdink ; Joost, M. Klaase ; Maximilian Bockhorn ; Frederik J. H. Hoogwater ; Maarten W. Nijkamp
von Christin Knickmeier ; Gaetan Aime Noubissi Nzeteu ; Bernhard F. Gibbs ; Frederik J.H. Hoogwater ; Maarten W. Nijkamp ; Maximilian Bockhorn ; Niels Helge Meyer
Sonja Loges ist fälschlich als "Sonia Loges" geschrieben ; Online verfügbar: 20. Februar 2025, Artikelversion: 27. Februar 2025 ; Gesehen am 27.05.2025
V-domain Ig-containing suppressor of T cell activation (VISTA) is a unique immune checkpoint protein, which was reported to display both receptor and ligand activities. However, the mechanisms of regulation of VISTA activity and functions by factors of tumour microenvironment (TME) remain unclear and understanding these processes is required in order to develop successful personalised cancer immunotherapeutic strategies and approaches. Here we report for the very first time that VISTA interacts with another immune checkpoint protein galectin-9 inside the cell most likely facilitating its interaction with TGF-β-activated kinase 1 (TAK1). This process is required for protection of lysosomes, which is crucial for many cell types and tissues. We found that VISTA expression can be differentially controlled by crucial factors present in TME, such as transforming growth factor beta type 1 (TGF-β) and hypoxia as well as other factors activating hypoxic signalling. We confirmed that involvement of these important pathways modulated by TME differentially influences VISTA expression in different cell types. These networks include: TGF-β-Smad3 pathway, TAK1 (TGF-β-activated kinase 1) or apoptosis signal-regulating kinase 1 (ASK1)-induced activation of activating transcription factor 2 (ATF-2) and hypoxic signalling pathway. Based on this work we determined the five critical functions of VISTA and the role of TME factors in controlling (modulating or downregulating) VISTA expression.
Cancer letters Amsterdam [u.a.] : Elsevier Science, 1975 616(2025) vom: Apr., Artikel-ID 217581, Seite 1-13 Online-Ressource
von Mylena D. Bos ; Jelmer E. Oor ; Lucas Goense ; Niels Helge Meyer ; Maximilian Bockhorn ; Frederik J. H. Hoogwater ; Joost M. Klaase ; Maarten W. Nijkamp
European Academy of Dermatology and Venereology Journal of the European Academy of Dermatology and Venereology Oxford [u.a.] : Wiley-Blackwell, 1991 38(2024), 3, Seite e278-e281 Online-Ressource
