von Sophie Gottschalk ; Hans-Helmut König ; Tina Mallon ; Josefine Schulze ; Jan Weber ; Silke Böttcher ; Uta Sekanina ; Thomas Asendorf ; Eva Hummers ; Michael H. Freitag ; Nils Schneider ; Tim Friede ; Friedemann Nauck ; Martin Scherer ; Gabriella Marx ; Judith Dams
von Sven Müller ; Dirk Alfons Weyhe ; Florian Herrle ; Philipp Horvath ; Robert Bachmann ; Viktor von Ehrlich-Treuenstätt ; Patrick Heger ; Nadir Nasir ; Christina Klose ; Alexander Ritz ; Anja Sander ; Erich Grohmann ; Colette Dörr-Harim ; André L. Mihaljevic
Incisional hernia is a frequent complication following loop ileostomy reversal. Incisional hernias are associated with morbidity, loss of health-related quality of life and costs and warrant the investigation of prophylactic measures. Prophylactic mesh implantation at the time of surgical stoma reversal has shown to be a promising and safe method to prevent incisional hernias in this setting. However, the efficacy of this method has not yet been investigated in a large multicentre randomised-controlled trial (RCT) with adequate external validity. The P.E.L.I.O.N. trial will evaluate the efficacy of prophylactic mesh reinforcement after loop ileostomy closure in decreasing the rate of incisional hernia versus standard closure alone.
Trials London : BioMed Central, 2000 24(2023) vom: Feb., Artikel-ID 76, Seite 1-17 Online-Ressource
Neurostimulation is a mainstream treatment option for major depression. Neuromodulation techniques apply repetitive magnetic or electrical stimulation to some neural target but significantly differ in their invasiveness, spatial selectivity, mechanism of action, and efficacy. Despite these differences, recent analyses of transcranial magnetic stimulation (TMS) and deep brain stimulation (DBS)-treated individuals converged on a common neural network that might have a causal role in treatment response. We set out to investigate if the neuronal underpinnings of electroconvulsive therapy (ECT) are similarly associated with this causal depression network (CDN). Our aim here is to provide a comprehensive analysis in three cohorts of patients segregated by electrode placement (N = 246 with right unilateral, 79 with bitemporal, and 61 with mixed) who underwent ECT. We conducted a data-driven, unsupervised multivariate neuroimaging analysis Principal Component Analysis (PCA) of the cortical and subcortical volume changes and electric field (EF) distribution to explore changes within the CDN associated with antidepressant outcomes. Despite the different treatment modalities (ECT vs TMS and DBS) and methodological approaches (structural vs functional networks), we found a highly similar pattern of change within the CDN in the three cohorts of patients (spatial similarity across 85 regions: r = 0.65, 0.58, 0.40, df = 83). Most importantly, the expression of this pattern correlated with clinical outcomes (t = −2.35, p = 0.019). This evidence further supports that treatment interventions converge on a CDN in depression. Optimizing modulation of this network could serve to improve the outcome of neurostimulation in depression.