von Timo Stöver ; Stefan Dazert ; Thomas K. Hoffmann ; Stefan K.-R. Plontke ; Petra Ambrosch ; Christoph Arens ; Christian Stephan Betz ; Dirk Beutner ; Christopher Bohr ; Karl-Ludwig Bruchhage ; Martin Canis ; Andreas Dietz ; Orlando Guntinas-Lichius ; Rudolf Hagen ; Werner Hosemann ; Heinrich Iro ; Jens Peter Klußmann ; Andreas Knopf ; Sabine Maria Kramer ; Stephan Lang ; Martin Leinung ; Thomas Lenarz ; Hubert Martin Löwenheim ; Christoph Matthias ; Robert Arndt Mlynski ; Heidi Olze ; Jonas Jae-Hyun Park ; Peter K. Plinkert ; Andreas Daniel Radeloff ; Nicole Rotter ; Claudia Rudack ; Alessandro Bozzato ; Jörg H. Schipper ; Martin Schrader ; Sebastian Strieth ; Boris Stuck ; Stefan Volkenstein ; Martin Westhofen ; Gregor Wolf ; Barbara Wollenberg ; Thomas Zahnert ; Johannes Zenk
von Klaus Edgar Roth ; Gerrit Steffen Maier ; Irene Maria Schmidtmann ; Ulrich Eigner ; Wolf Dietrich Hübner ; Fabian Peters ; Philipp Drees ; Uwe Martin Maus
von David Capper ; David T. W. Jones ; Daniel Schrimpf ; Dominik Sturm ; Christian Kölsche ; Felix Sahm ; David Reuss ; Annekathrin Kratz ; Annika K. Wefers ; Kristin Huang ; Kristian Wilfried Pajtler ; Leonille Schweizer ; Damian Stichel ; Florian Selt ; Hendrik Witt ; Till Milde ; Olaf Witt ; Wolfram Scheurlen ; Christoph Geisenberger ; Stefanie Brehmer ; Marcel Seiz-Rosenhagen ; Daniel Hänggi ; Andreas Kulozik ; Axel Benner ; Martin Bendszus ; Jürgen Debus ; Michael Platten ; Andreas Unterberg ; Wolfgang Wick ; Marcel Kool ; Christel Herold-Mende ; Andreas von Deimling ; Stefan Pfister ; Hermann L. Müller
Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challenging—with substantial inter-observer variability in the histopathological diagnosis of many tumour types. Here we present a comprehensive approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups, and demonstrate its application in a routine diagnostic setting. We show that the availability of this method may have a substantial impact on diagnostic precision compared to standard methods, resulting in a change of diagnosis in up to 12% of prospective cases. For broader accessibility, we have designed a free online classifier tool, the use of which does not require any additional onsite data processing. Our results provide a blueprint for the generation of machine-learning-based tumour classifiers across other cancer entities, with the potential to fundamentally transform tumour pathology.
Nature London [u.a.] : Nature Publ. Group, 1869 555(2018), 7697, Seite 469-474 Online-Ressource
von Maximilian von Laffert ; Peter Schirmacher ; Arne Warth ; W. Weichert ; R. Büttner ; R. M. Huber ; J. Wolf ; Frank Griesinger ; M. Dietel ; C. Grohé
The EML4-ALK pathway plays an important role in a significant subset of non-small cell lung cancer patients. Treatment options such as ALK tyrosine kinase inhibitors lead to improved progression free survival and overall survival. These therapeutic options are chosen on the basis of the identification of the underlying genetic signature of the EML-ALK translocation. Efficient and easily accessible testing tools are required to identify eligible patients in a timely fashion. While FISH techniques are commonly used to detect this translocation, the broad implementation of this type of ALK testing into routine diagnostics is not optimal due to technical, structural and financial reasons. Immunohistochemical techniques to screen for EML4-ALK translocations may therefore play an important role in the near future. This consensus paper provides recommendations for the test algorithm and quality of the respective test approaches, which are discussed in the light of the current literature.
Lung cancer Amsterdam [u.a.] : Elsevier, 1985 103(2017), Seite 1-5 Online-Ressource
von Renke Lühken ; Christina Czajka ; Sonja Steinke ; Jonas Schmidt-Chanasit ; Wolf Peter Pfitzner ; Norbert Becker ; Ellen Kiel ; Andreas Krüger ; Egbert Tannich
von Maximilian von Laffert ; Peter Schirmacher ; Arne Warth ; Wilko Weichert ; Reinhard Büttner ; R. M. Huber ; Jürgen Wolf ; Frank Griesinger ; Manfred Dietel ; Christian Grohé
von Maximilian von Laffert ; Peter Schirmacher ; Arne Warth ; Wilko Weichert ; Reinhard Büttner ; R. M. Huber ; J. Wolf ; Frank Griesinger ; Manfred Dietel ; C. Grohé
von Renke Lühken ; Wolf Peter Pfitzner ; Jessica Börstler ; Rolf Garms ; KAtrin Huber ; Nino Schork ; Sonja Steinke ; Ellen Kiel ; Norbert Becker ; Egbert Tannich ; Andreas Krüger
To monitor adult mosquitoes several trapping devices are available. These are differently constructed and use various mechanisms for mosquito attraction, thus resulting in different trapping sensitivities and efficacies for the various species. Mosquito monitoring and surveillance programs in Europe use various types of mosquito traps, but only a few comparisons have been conducted so far. This study compared the performance of four commercial trapping devices, which are commonly used in Europe.
Parasites & vectors London : BioMed Central, 2008 7(2014), Artikel-ID 268, Seite 1-11 Online-Ressource
QuelleBayernTaufeBaptistenEvangelisch-Lutherische Kirche in BayernÖkumenische TheologieGeschichte 2009TheologieBaptistBaptistinSakramentPfalz-BayernLutherische KircheMünchenEvangelisch-Lutherische Landeskirche in Bayern Rechts des Rheins1921-
Zeitschrift für Theologie und Gemeinde Hamburg : Verlag der GFTP, 1996 15(2010), Seite 313-340
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