von Patrick Wagner ; Nils Strodthoff ; Patrick Wurzel ; Arturo Marban ; Sonja Scharf ; Hendrik Schäfer ; Philipp Seegerer ; Andreas Loth ; Sylvia Hartmann ; Frederick Klauschen ; Klaus-Robert Müller ; Wojciech Samek ; Martin-Leo Hansmann
Online first: 8 January 2021 ; Gesehen am 16.07.2021
First-line therapy for younger patients with peripheral T-cell non-Hodgkin lymphoma (T-NHL) consists of 6 courses of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) with or without etoposide (CHOEP), consolidated by high-dose therapy and autologous stem cell transplantation (auto-SCT). We hypothesized that allogeneic stem cell transplantation (allo-SCT) could improve outcomes. 104 patients with peripheral T-cell non-Hodgkin lymphoma, except ALK+ anaplastic large cell lymphoma, 18 to 60 years, all stages, and all age adjusted International Prognostic Index scores, except 0 and stage I, were randomized to 4 cycles of CHOEP and 1 cycle of dexamethasone, cytosine-arabinoside, and platinum (DHAP) followed by high-dose therapy and auto-SCT or myeloablative conditioning and allo-SCT. The primary end point was event-free survival (EFS) at 3 years. After a median follow-up of 42 months, the 3-year EFS after allo-SCT was 43%, as compared with 38% after auto-SCT. Overall survival at 3 years was 57% vs 70% after allo- or auto-SCT, without significant differences between treatment arms. None of the 21 responding patients proceeding to allo-SCT relapsed, as opposed to 13 of 36 patients (36%) proceeding to auto-SCT. Eight of 26 patients (31%) and none of 41 patients died of transplant-related toxicity after allo- and auto-SCT, respectively. The strong graft-versus-lymphoma effect after allo-SCT was counterbalanced by transplant-related mortality. This trial is registered at www.clinicaltrials.gov as #NCT00984412.
Blood Washington, DC : American Society of Hematology, 1946 137(2021), 19 vom: 13. Mai, Seite 2646-2656 Online-Ressource
von Mathias Milici ; Marius Vital ; Jürgen Martin Tomasch ; Thomas H. Badewien ; Helge-Ansgar Giebel ; Iris Plumeier ; Hui Wang ; Dietmar Helmut Pieper ; Irene Wagner-Döbler ; Meinhard Simon
von Thomas Riedel ; Laura Gómez-Consarnau ; Jürgen Tomasch ; Madeleine Martin ; Michael Jarek ; José M. González ; Stefan Spring ; Meike Rohlfs ; Thorsten Brinkhoff ; Heribert Cypionka
National Academy of Sciences (Washington, DC) Proceedings of the National Academy of Sciences of the United States of America Washington, DC : NAS, 1877 108(2011), 20 vom: 17. Mai, Seite 8420-8425
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