von Marlies Bongers ; Stephen D. Quinn ; Michael D. Mueller ; Bernhard Krämer ; Benjamin Tuschy ; Marc Sütterlin ; Ricardo Bassil Lasmar ; Andreas Thurkow ; Rudy Leon de Wilde
von Hermann L. Müller ; Johannes H. M. Merks ; Birgit Geoerger ; Jacques Grill ; Darren Hargrave ; Julia Glade Bender ; Sridharan Gururangan ; Fariba Navid ; Michael Johnston ; Jeanette Bachir ; Markus C. Elze ; Sabine Fürst-Recktenwald
von Sven Dittrich ; Joseph George Pattathu ; Friedrich Ebinger ; Joachim Eichhorn ; Reinald Motz ; Christoph Korenke ; Matthias Freund ; Michael Schumacher
X-linked Duchenne muscular dystrophy (DMD), the most frequent human hereditary skeletal muscle myopathy, inevitably leads to progressive dilated cardiomyopathy. We assessed the effect and safety of a combined treatment with the ACE-inhibitor enalapril and the β-blocker metoprolol in a German cohort of infantile and juvenile DMD patients with preserved left ventricular function.
Orphanet journal of rare diseases London : BioMed Central, 2006 14(2019), Artikel-ID 105, Seite 1-13 Online-Ressource
von David Capper ; David T. W. Jones ; Daniel Schrimpf ; Dominik Sturm ; Christian Kölsche ; Felix Sahm ; David Reuss ; Annekathrin Kratz ; Annika K. Wefers ; Kristin Huang ; Kristian Wilfried Pajtler ; Leonille Schweizer ; Damian Stichel ; Florian Selt ; Hendrik Witt ; Till Milde ; Olaf Witt ; Wolfram Scheurlen ; Christoph Geisenberger ; Stefanie Brehmer ; Marcel Seiz-Rosenhagen ; Daniel Hänggi ; Andreas Kulozik ; Axel Benner ; Martin Bendszus ; Jürgen Debus ; Michael Platten ; Andreas Unterberg ; Wolfgang Wick ; Marcel Kool ; Christel Herold-Mende ; Andreas von Deimling ; Stefan Pfister ; Hermann L. Müller
Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challenging—with substantial inter-observer variability in the histopathological diagnosis of many tumour types. Here we present a comprehensive approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups, and demonstrate its application in a routine diagnostic setting. We show that the availability of this method may have a substantial impact on diagnostic precision compared to standard methods, resulting in a change of diagnosis in up to 12% of prospective cases. For broader accessibility, we have designed a free online classifier tool, the use of which does not require any additional onsite data processing. Our results provide a blueprint for the generation of machine-learning-based tumour classifiers across other cancer entities, with the potential to fundamentally transform tumour pathology.
Nature London [u.a.] : Nature Publ. Group, 1869 555(2018), 7697, Seite 469-474 Online-Ressource
von Helge Bruelheide ; Jürgen Dengler ; Oliver Purschke ; Jonathan Lenoir ; Borja Jiménez-Alfaro ; Stephan M. Hennekens ; Zoltán Botta-Dukát ; Milan Chytrý ; Richard Field ; Florian Jansen ; Jens Kattge ; Valério D. Pillar ; Franziska Schrodt ; Miguel Mahecha ; Robert K. Peet ; Brody Sandel ; Peter van Bodegom ; Jan Altman ; Esteban Alvarez-Dávila ; Mohammed A. S. Arfin Khan ; Fabio Attorre ; Isabelle Aubin ; Christopher Baraloto ; Jorcely G. Barroso ; Marijn Bauters ; Erwin Bergmeier ; Idoia Biurrun ; Anne D. Bjorkman ; Benjamin Blonder ; Andraž Čarni ; Luis Cayuela ; Tomáš Černý ; J. Hans C. Cornelissen ; Dylan Craven ; Matteo Dainese ; Géraldine Derroire ; Michele De Sanctis ; Sandra Díaz ; Jiří Doležal ; William Farfan-Rios ; Ted R. Feldpausch ; Nicole J. Fenton ; Eric Garnier ; Greg R. Guerin ; Alvaro G. Gutiérrez ; Sylvia Simone Rebekka Haider ; Tarek Hattab ; Greg Henry ; Bruno Hérault ; Pedro Higuchi ; Norbert Hölzel ; Jürgen Homeier ; Anke Jentsch-Beierkuhnlein ; Norbert Jürgens ; Zygmunt Kącki ; Dirk N. Karger ; Michael Kessler ; Michael Kleyer ; Ilona Knollová ; Andrey Y. Korolyuk ; Ingolf Kühn ; Daniel C. Laughlin ; Frederic Lens ; Jacqueline Loos ; Frédérique Louault ; Mariyana I. Lyubenova ; Yadvinder Malhi ; Corrado Marcenò ; Maurizio Mencuccini ; Jonas V. Müller ; Jérôme Munzinger ; Isla H. Myers-Smith ; David A. Neill ; Ülo Niinemets ; Kate H. Orwin ; Wim A. Ozinga ; Josep Penuelasm ; Aaron Pérez-Haase ; Petr Petřík ; Oliver L. Phillips ; Meelis Pärtel ; Peter B. Reich ; Christine Römermann ; Arthur V. Rodrigues ; Francesco Maria Sabatini ; Jordi Sardans ; Marco Schmidt ; Gunnar Seidler ; Javier Eduardo Silva Espejo ; Marcos Silveira ; Anita Smyth ; Maria Sporbert ; Jens-Christian Svenning ; Zhiyao Tang ; Raquel Thomas ; Ioannis Tsiripidis ; Kiril Vassilev ; Cyrille Violle ; Risto Virtanen ; Evan Weiher ; Erik Welk ; Karsten Wesche ; Marten Winter ; Christian Wirth ; Ute Jandt
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