von Julian Müller ; Ivaylo Chakarov ; Philipp Halbfaß ; Karin Nentwich ; Elena Ene ; Artur Berkovitz ; Kai Sonne ; Sebastian Barth ; Christian Waechter ; Tobias Schupp ; Michael Behnes ; Ibrahim Akın ; Thomas Deneke
Background: Electrical storm (ES) represents a serious heart rhythm disorder. This study investigates the impact of ES on acute ablation success and long-term outcomes after VT ablation compared to non-ES patients. Methods: In this large single-centre study, patients presenting with ES and undergoing VT ablation from June 2018 to April 2021 were compared to patients undergoing VT ablation due to ventricular tachyarrhythmias but without ES. The primary prognostic outcome was VT recurrence, and secondary endpoints were rehospitalization rates and cardiovascular mortality, all after a median follow-up of 22 months. Results: A total of 311 patients underwent a first VT ablation due to ventricular tachyarrhythmias and were included (63 ± 14 years; 86% male). Of these, 108 presented with ES. In the ES cohort, dilated cardiomyopathy as underlying heart disease was significantly higher (p = 0.008). Major complications were equal across both groups (all p > 0.05). Ablation of the clinical VT was achieved in 94% of all patients (p > 0.05). Noninducibility of any VT was achieved in 91% without ES and in 76% with ES (p = 0.001). Patients with ES revealed increased VT recurrence rates during follow-up (65% vs. 40%; log rank p = 0.001; HR 1.841, 95% CI 1.289-2.628; p = 0.001). Furthermore, ES patients suffered from increased rehospitalization rates (73% vs. 48%; log rank p = 0.001; HR 1.948, 95% CI 1.415-2.682; p = 0.001) and cardiovascular mortality (18% vs. 9%; log rank p = 0.045; HR 1.948, 95% CI 1.004-3.780; p = 0.049). After multivariable adjustment, ES was a strong independent predictor of VT recurrence and rehospitalization rates, but not for mortality. In a propensity score-matched cohort, patients with ES still had a higher risk of VT recurrences and rehospitalizations compared to non-ES patients. Conclusions: VT ablation in patients with ES is challenging and these patients reveal the highest risk for recurrent VTs, rehospitalization and cardiovascular mortality. These patients need close follow-ups and optimal guideline-directed therapy.
Journal of Clinical Medicine Basel : MDPI, 2012 12(2023), 7 vom: Apr., Seite 1-15 Online-Ressource
Heiko Hausendorf; Joachim Scharloth; Kyoko Sugisaki; Noah BubenhoferNoah Bubenhofer; Heiko Hausendorf; Joachim Scharloth; Kyoko Sugisaki
Michael Bender; Noah Bubenhofer; Selena Calleri; Hajo Diekmannshenke; Christina Gansel; Heiko Hausendorf; Maaike Kellenberger; David Koch; Jan Langenhorst; Marie-Luis Merten; Marcus Müller; Marcel Naef; Joachim Scharloth; Kyoko Sugisaki; Nicolas Wiedmer; Stephan Wolff
Postcards -- History; Postcards -- Social aspects; Text; Ansichtskarte; LITERARY CRITICISM / European / German; Tourismus; Gruß; Postcard; Medien; LITERARY CRITICISM / General; Kultur; Urlaub; LANGUAGE ARTS & DISCIPLINES / Linguistics / General; Sprache; Kulturgeschichte; Bild; Literatur; Sprachwissenschaft; HISTORY / Social History; Germanistik; Postkarte; Literaturwissenschaft; Cultural History; Culture; German Literature; Greeting; Holidays; Image; Language; Linguistics; Literary Studies; Literature; Media; Tourism; Aufsatzsammlung; Deutsch; Ansichtspostkarte; Linguistik; Kulturanalyse; Open Access
Frontmatter
Inhalt
Vorwort
Ansichtskarten als Gegenstand: Methodologische Aspekte
Ansonsten radeln wir viel
Rituelle Wechselnichtigkeiten
[anko] - Ansichtskartenkorpus
Strukturwandel der Urlaubswelt(en)
Grüße aus Trujillo
Was auf Ansichtskarten geschrieben steht
Codeswitching auf Ansichtskarten
Wie kurz ist eine Ansichtskarte?
Feriengrüße positionierungstheoretisch
Sport im Urlaub?
»s'Bild isch kein bschiss!«
»Man gewöhnt sich an alles«
Reisen und die Zeit
Die dunkle Seite der Ansichtskarte
Anhang
Dokumentation des Ansichtskartenkorpus
Autor*innenverzeichnis
Die Ansichtskarte ist ein Erfolgsmedium des 20. Jahrhunderts. Mit ihrer Beidseitigkeit von Text und Bild ist sie seit der Nachkriegszeit zur Ikone des modernen Massentourismus geworden. Den Gruß aus der Ferne mit Mitteilungen über das Erlebte zu verbinden, gehört seither zu den Alltagsritualen des Urlaubs. Aber was genau schreiben Menschen auf Ansichtskarten? Welche sprachlich-kommunikativen Muster des Urlaubsgrußes haben sich bewährt und wie haben sie sich im Laufe der Jahrzehnte verändert? Und droht die Ansichtskarte angesichts der Konkurrenz elektronischer Nachfolger auszusterben? Die Beiträger*innen des Bandes gehen diese Fragen unter korpus-, text- und kulturlinguistischen Gesichtspunkten empirisch nach
von Dominik Sturm ; David Capper ; Felipe Andreiuolo ; Marco Gessi ; Christian Kölsche ; Annekathrin Reinhardt ; Philipp Sievers ; Annika K. Wefers ; Azadeh Ebrahimi ; Abigail Kora Suwala ; Gerrit H. Gielen ; Martin Sill ; Daniel Schrimpf ; Damian Stichel ; Volker Hovestadt ; Bjarne Daenekas ; Agata Rode ; Stefan Hamelmann ; A. Christopher Previti ; Natalie Jäger ; Ivo Buchhalter ; Mirjam Blattner-Johnson ; Barbara Christine Jones ; Monika Warmuth-Metz ; Brigitte Bison ; Kerstin Grund ; Christian Sutter ; Steffen Hirsch ; Nicola Dikow ; Olaf Witt ; Andreas von Deimling ; Hermann L. Müller ; Torsten Pietsch ; Felix Sahm ; Stefan Pfister ; David T. W. Jones
Cancer epidemiology; Cancer epigenetics; CNS cancer; Diagnostic markers; Paediatric cancer
The large diversity of central nervous system (CNS) tumor types in children and adolescents results in disparate patient outcomes and renders accurate diagnosis challenging. In this study, we prospectively integrated DNA methylation profiling and targeted gene panel sequencing with blinded neuropathological reference diagnostics for a population-based cohort of more than 1,200 newly diagnosed pediatric patients with CNS tumors, to assess their utility in routine neuropathology. We show that the multi-omic integration increased diagnostic accuracy in a substantial proportion of patients through annotation to a refining DNA methylation class (50%), detection of diagnostic or therapeutically relevant genetic alterations (47%) or identification of cancer predisposition syndromes (10%). Discrepant results by neuropathological WHO-based and DNA methylation-based classification (30%) were enriched in histological high-grade gliomas, implicating relevance for current clinical patient management in 5% of all patients. Follow-up (median 2.5 years) suggests improved survival for patients with histological high-grade gliomas displaying lower-grade molecular profiles. These results provide preliminary evidence of the utility of integrating multi-omics in neuropathology for pediatric neuro-oncology.
Nature medicine [New York, NY] : Springer Nature, 1995 29(2023), 4, Seite 917-926 Online-Ressource
atrial fibrillation; endoscopically detected esophageal lesion; prognosis; pulmonary vein isolation; very high-power short duration ablation
Background: This study sought to evaluate the short and midterm efficacy and safety of the novel very high power very short duration (vHPvSD) 90 W approach compared to HPSD 50 W for atrial fibrillation (AF) ablation as well as reconnection patterns of 90 W ablations. Methods and Results: Consecutive patients undergoing first AF ablation with vHPvSD (90 W; predefined ablation time of 3 s for posterior wall ablation and 4 s for anterior wall ablation) were compared to patients using HPSD (50 W; ablation index-guided; AI 350 for posterior wall ablation, AI 450 for anterior wall ablation) retrospectively. A total of 84 patients (67.1 ± 9.8 years; 58% male; 47% paroxysmal AF) were included (42 with 90 W, 42 with 50 W) out of a propensity score-matched cohort. 90 W ablations revealed shorter ablation times (10.5 ± 6.7 min vs. 17.4 ± 9.9 min; p = .001). No major complication occurred. 90 W ablations revealed lower first pass PVI rates (40% vs. 62%; p = .049) and higher AF recurrences during blanking period (38% vs. 12%; p = .007). After 12 months, both ablation approaches revealed comparable midterm outcomes (62% vs. 70%; log-rank p = .452). In a multivariable Cox regression model, persistent AF (hazard ratio [HR]: 1.442, 95% confidence interval [CI]: 1.035-2.010, p = .031) and increased procedural duration (HR: 1.011, 95% CI: 1.005-1.017, p = .001) were identified as independent predictors of AF recurrence during follow-up. Conclusions: AF ablation using 90 W vHPvSD reveals a similar safety profile compared to 50 W ablation with shorter ablation times. However, vHPvSD ablation was associated with lower rates of first-pass isolations and increased AF recurrences during the blanking period. After 12 months, 90 W revealed comparable efficacy results to 50 W ablations in a nonrandomized, propensity-matched comparison.
Journal of cardiovascular electrophysiology Oxford : Wiley-Blackwell, 1990 33(2022), 12, Seite 2504-2513 Online-Ressource
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