von Lea Flämig ; Thomas Schidelko ; Luca Blicker ; Katharina Hoffmann ; Constantin Gabriel Daniliuc ; Dirk Schepmann ; Marcel Bermúdez ; Karin Loser ; Bernhard Wünsch
Meningeome sind im Kindes- und Jugendalter selten. Es existieren kaum Daten zur gesundheitsbezogenen Lebensqualität (Health-Related Quality of Life, HRQoL) von pädiatrischen Meningeompatient*innen. In einer Querschnittsstudie wurde nun die HRQoL von 35 dieser Patient*innen nach beendeter Therapie mittels Fragebögen erhoben. Dies fand im Median 10 Jahre nach Diagnose statt. Minderjährige Teilnehmende erreichten nach dem PedsQL Fragebogen eine mediane HRQoL von 86 und adulte Teilnehmende nach dem EORTC QLQ-C30 Fragebogen von 75. Erwachsene mit NF2 gaben eine niedrigere HRQoL an. Ein Rezidiv/Progress ging mit einer höheren HRQoL einher. Das Alter bei Diagnose, der WHO-Grad, Tumorreste, Strahlentherapie, die Tumorlokalisation, die Tumorentität, der Grad der Behinderung und die Zeit seit Diagnose zeigten keinen Einfluss. Diese Studie bietet Hinweise, dass pädiatrische Meningeompatient*innen nach abgeschlossener Therapie eine mit der Allgemeinbevölkerung vergleichbare HRQoL aufweisen.
Meningiomas are rare in children and adolescents. There is limited data on health-related quality of life (HRQoL) of pediatric meningioma patients. In a cross-sectional study the HRQoL of 35 of these patients was analysed using questionnaires after completion of therapy. HRQoL was assessed in median 10 years after diagnosis. The child and adolescent study participants achieved a mean HRQoL score of 86 according to the PedsQL Generic Core Scale. The adult study participants achieved a mean HRQoL score of 75 according to the EORTC QLQ-C30 questionnaire. Adult participants with NF2 reported lower HRQoL. Recurrence or progression was associated with higher HRQoL. Age at diagnosis, WHO grade, residual tumor, radiotherapy, tumor location, tumor entity, degree of disability and time since diagnosis did not affect the HRQoL. This study provides data suggesting that paediatric meningioma patients have HRQoL comparable to that of the general population after completing therapy.
von Anna Teresa Hoffmann ; Robin Kobbe ; Robin Denz ; Christoph Maier ; Nicole Toepfner ; Nina Timmesfeld ; Astrid Petersmann ; Axel Hamprecht ; Yadwinder Kaur
Veröffentlicht: 05. Dezember 2024 ; Gesehen am 10.06.2025
Global Health; Health status; Infectious diseases; Intrafamilial spread; Maternal and Child Health; Migration and Health; Minor refugees; Public Health; Risk Factors; Social Work and Migration; Ukraine; Vaccination status
In 2022, over 1,000,000 people from Ukraine fled to Germany, mostly women and children. The aim of this study was to determine health status and socio-demographic background of Ukrainian refugee minors in Germany and to compare that to German minors. In this study, Ukrainian refugees of all ages, who voluntarily made contact with the study centres via flyers or refugee shelters, were interviewed with the help of trained interpreters from 09–12/2022. We assessed data from minors and their families on socio-economic status, general health perception, current and pre-existing infectious and non-contagious diseases, and vaccination status. The data for the minors were collected by interviewing the accompanying adults. In addition, a physical examination and serological screening for infectious and vaccine-preventable diseases were performed. Overall, 392 minors and accompanying adults (358) were included. Minors’ general and mental health were reported as “at least good" in 83% (316) and 80% (304), respectively. In 16% (63), infectious or other underlying diseases were recorded. Tuberculosis infections (7, 1.8%) and hepatitis C (2, 0.5%) were found through the serological tests. HIV could only be detected in one previously known case. Self-reported vaccinations against measles and varicella, for example, did not match serological findings (protection against measles 304; 84%; varicella 230; 64%). Conclusion: Accompanying adults often rate the general health and well-being of Ukrainian refugee minors as rather poor. Frequently, self-reported vaccinations and preexisting diseases did not match serology results; therefore, Ukrainian refugee minors without formal vaccination certificate should be offered all recommended vaccinations and be generously screened for hepatitis B, C and HIV in addition to tuberculosis.
European journal of pediatrics Berlin : Springer Science & Business Media B.V., 1975 184(2025), 1, Artikel-ID 64, Seite 1-15 Online-Ressource
von Friedrich Tobias Ingo Rothoeft ; Anna Teresa Hoffmann ; Christoph Maier ; Robin Denz ; Robin Kobbe ; Anette Friedrichs ; Georg Martin Norbert Behrens ; Pia Behrens ; Reinhard Berner ; Amke Caliebe ; Claudia M. Denkinger ; Katharina Giesbrecht ; Leonhard Hojenski ; Olga Hovardovska ; Alexandra Jablonka ; Olga Iatseniuk ; Achim Kaasch ; Monika Kraus ; Lazar Mitrov ; Matthias Nauck ; Susana Marina Nunes de Miranda ; Margarete Scherer ; Yvonne Schmiedel ; Dana Stahl ; Nina Timmesfeld ; Nicole Marina Töpfner ; Jörg Janne Vehreschild ; Walter A. Wohlgemuth ; Astrid Petersmann ; Maria J. G. T. Vehreschild ; Folke Brinkmann
Age dependency; Convalescent; COVID-19; IGRA; Immunity; SARS-CoV-2; T cell; Vaccination
Introduction: A lot of research has been done, mainly on tuberculosis (TB), on the extent to which cellular immune protection as measured by interferon-γ release assays (IGRA) is age-dependent. In a previous study we showed that following an Omicron infection, adolescents with a hybrid immunity had a higher probability of having a reactive SARS-CoV-2-specific IGRA than children. Therefore, we examined in a large group of minors and adults whether age influences cellular immunity as measured by IGRA in TB and SARS-CoV-2. Methods: Participants were recruited at 13 German study sites between September and December 2022. Cellular immunity was analyzed using SARS-CoV-2 and Tb-specific IGRA and humoral immunity against SARS-CoV-2 by measuring antibodies against spike (S) and nucleocapsid protein. Analysis was done depending on natural (convalescent, not vaccinated) or hybrid immunity (convalescent and vaccinated). Results: Overall, 1401 adults and 392 minors were included. The amount of interferon-γ released by T cells, as well as the probability of a positive SARS-CoV-2 IGRA (OR 1.022) and a positive Tb IGRA (OR 1.047) were age dependent. Sensitivity of SARS-CoV-2 IGRA in natural immunity was lower in minors (0.45), especially in those less than 5 years (0.29) as compared to adults (0.66). Conclusion: The interferon-γ response to SARS-CoV-2 infections and/or vaccinations and to Tb infections as measured by IGRA is in quality and quantity dependent on age. The sensitivity of commercially available tests in young children seems to be suboptimal, limiting their use as a diagnostic or research tool in this age group.
Infection München : Urban & Vogel, 1973 53(2025), 6 vom: Dez., Seite 2669-2680 Online-Ressource
