von Jürgen Beck ; Christian Fung ; Daniel Strbian ; Lukas Bütikofer ; Werner J. Z'Graggen ; Matthias F. Lang ; Seraina Beyeler ; Jan Gralla ; Florian Ringel ; Karl Schaller ; Nikolaus Plesnila ; Marcel Arnold ; Werner Hacke ; Peter Jüni ; Alexander David Mendelow ; Christian Stapf ; Rustam Al-Shahi Salman ; Jenny Bressan ; Stefanie Lerch ; Arsany Hakim ; Nicolas Martinez-Majander ; Anna Piippo-Karjalainen ; Peter Vajkoczy ; Stefan Wolf ; Gerrit A. Schubert ; Anke Höllig ; Michael Veldeman ; Roland Rölz ; Andreas Gruber ; Philip Rauch ; Dorothee Wachter ; Veit Rohde ; Thomas Kerz ; Eberhard Uhl ; Enea Thanasi ; Hagen B. Huttner ; Bernd Kallmünzer ; L. Jaap Kappelle ; Wolfgang Deinsberger ; Christian Roth ; Robin Lemmens ; Jan Leppert ; Jose L. Sanmillan ; Jonathan M. Coutinho ; Katharina Hackenberg ; Gernot Reimann ; Mikael Mazighi ; Claudio L. A. Bassetti ; Heinrich P. Mattle ; Andreas Raabe ; Urs Fischer
BACKGROUND: It is unknown whether decompressive craniectomy improves clinical outcome for people with spontaneous severe deep intracerebral haemorrhage. The SWITCH trial aimed to assess whether decompressive craniectomy plus best medical treatment in these patients improves outcome at 6 months compared to best medical treatment alone. METHODS: In this multicentre, randomised, open-label, assessor-blinded trial conducted in 42 stroke centres in Austria, Belgium, Finland, France, Germany, the Netherlands, Spain, Sweden, and Switzerland, adults (18-75 years) with a severe intracerebral haemorrhage involving the basal ganglia or thalamus were randomly assigned to receive either decompressive craniectomy plus best medical treatment or best medical treatment alone. The primary outcome was a score of 5-6 on the modified Rankin Scale (mRS) at 180 days, analysed in the intention-to-treat population. This trial is registered with ClincalTrials.gov, NCT02258919, and is completed. FINDINGS: SWITCH had to be stopped early due to lack of funding. Between Oct 6, 2014, and April 4, 2023, 201 individuals were randomly assigned and 197 gave delayed informed consent (96 decompressive craniectomy plus best medical treatment, 101 best medical treatment). 63 (32%) were women and 134 (68%) men, the median age was 61 years (IQR 51-68), and the median haematoma volume 57 mL (IQR 44-74). 42 (44%) of 95 participants assigned to decompressive craniectomy plus best medical treatment and 55 (58%) assigned to best medical treatment alone had an mRS of 5-6 at 180 days (adjusted risk ratio [aRR] 0·77, 95% CI 0·59 to 1·01, adjusted risk difference [aRD] -13%, 95% CI -26 to 0, p=0·057). In the per-protocol analysis, 36 (47%) of 77 participants in the decompressive craniectomy plus best medical treatment group and 44 (60%) of 73 in the best medical treatment alone group had an mRS of 5-6 (aRR 0·76, 95% CI 0·58 to 1·00, aRD -15%, 95% CI -28 to 0). Severe adverse events occurred in 42 (41%) of 103 participants receiving decompressive craniectomy plus best medical treatment and 41 (44%) of 94 receiving best medical treatment. INTERPRETATION: SWITCH provides weak evidence that decompressive craniectomy plus best medical treatment might be superior to best medical treatment alone in people with severe deep intracerebral haemorrhage. The results do not apply to intracerebral haemorrhage in other locations, and survival is associated with severe disability in both groups. FUNDING: Swiss National Science Foundation, Swiss Heart Foundation, Inselspital Stiftung, and Boehringer Ingelheim.
The lancet London [u.a.] : Elsevier, 1823 403(2024), 10442 vom: Juni, Seite 2395-2404 Online-Ressource
Ausgehend von Indenylethylaminen konnten neuartige Dimethyltitankomplexe dargestellt und vollständig charakterisiert werden. Abhängig vom Substituenten am Stickstoffatom des Indenylethylamins zeigten die Komplexe unterschiedliche katalytische Aktivitäten in verschiedenen inter- und intramolekularen Hydroaminierungs- und Hydroaminoalkylierungsreaktionen. Zudem wurden α-Thienylmethylamine mit Styrol zu den linearen intermolekularen Hydroaminoalkylierungsprodukten umgesetzt. Außerdem konnten 2-Allylfuran, 2-Allylthiophen und furyl-, thienyl- und benzothienylsubstituierte Allyl- und Vinylsilane mit N-Methylanilinen in der intermolekularen Hydroaminoalkylierung umgesetzt werden. Darüber hinaus wurde ein Bromsubstituent am Heteroaromaten toleriert, sodass die entsprechenden Hydroaminoalkylierungsprodukte in einer anschließenden Buchwald-Hartwig-Aminierung umgesetzt werden konnten. Auf diese Weise konnten in einem Eintopfverfahren bisher literaturunbekannte anellierte Ringsysteme erzeugt werden. <dt.>
In this work novel dimethyl titanium complexes were prepared and fully characterized, starting from indenylethylamines. Depending on the substituent on the nitrogen atom of indenylethylamine, the complexes showed different catalytic activities in various inter- and intramolecular hydroamination and hydroaminoalkylation reactions. In addition, α-thienyl amines were reacted with styrene to give the linear intermolecular hydroaminoalkylation products. 2-Allylfuran and 2-allylthiophene and furyl, thienyl and benzothienyl substituted allyl and vinyl silanes were also reacted with N-methylanilines in an intermolecular hydroaminoalkylation reaction. An additional bromo substituent on the heteroaromatic system was tolerated, too. The hydroaminoalkylation products resulting from the bromo substituted alkenes were reacted in a Buchwald-Hartwig-amination. In this way, it was possible to produce literature-unknown fused ring systems in a one-pot procedure. <engl.>
Ausgehend von Indenylethylaminen konnten neuartige Dimethyltitankomplexe dargestellt und vollständig charakterisiert werden. Abhängig vom Substituenten am Stickstoffatom des Indenylethylamins zeigten die Komplexe unterschiedliche katalytische Aktivitäten in verschiedenen inter- und intramolekularen Hydroaminierungs- und Hydroaminoalkylierungsreaktionen. Zudem wurden α-Thienylmethylamine mit Styrol zu den linearen intermolekularen Hydroaminoalkylierungsprodukten umgesetzt. Außerdem konnten 2-Allylfuran, 2-Allylthiophen und furyl-, thienyl- und benzothienylsubstituierte Allyl- und Vinylsilane mit N-Methylanilinen in der intermolekularen Hydroaminoalkylierung umgesetzt werden. Darüber hinaus wurde ein Bromsubstituent am Heteroaromaten toleriert, sodass die entsprechenden Hydroaminoalkylierungsprodukte in einer anschließenden Buchwald-Hartwig-Aminierung umgesetzt werden konnten. Auf diese Weise konnten in einem Eintopfverfahren bisher literaturunbekannte anellierte Ringsysteme erzeugt werden.
In this work novel dimethyl titanium complexes were prepared and fully characterized, starting from indenylethylamines. Depending on the substituent on the nitrogen atom of indenylethylamine, the complexes showed different catalytic activities in various inter- and intramolecular hydroamination and hydroaminoalkylation reactions. In addition, α-thienyl amines were reacted with styrene to give the linear intermolecular hydroaminoalkylation products. 2-Allylfuran and 2-allylthiophene and furyl, thienyl and benzothienyl substituted allyl and vinyl silanes were also reacted with N-methylanilines in an intermolecular hydroaminoalkylation reaction. An additional bromo substituent on the heteroaromatic system was tolerated, too. The hydroaminoalkylation products resulting from the bromo substituted alkenes were reacted in a Buchwald-Hartwig-amination. In this way, it was possible to produce literature-unknown fused ring systems in a one-pot procedure.
SafeTRANS : Safety, Testen und Entwicklungsprozesse hochautomatisierter Systeme
von Eckard Böde ; Heinrich Daembkes ; Werner Damm ; Franziska Griebel ; Frank Köster ; Karsten Lemmer ; Andreas Lüdtke ; Jürgen Niehaus ; Thomas Peikenkamp
