von Jens P. Dreier ; Coline L. Lemale ; Viktor Horst ; Sebastian Major ; Vasilis Kola ; Karl Schoknecht ; Michael Lothar Scheeler ; Jed A. Hartings ; Peter Vajkoczy ; Stefan Wolf ; Johannes Woitzik ; Nils Nicholas Hecht
von Balázs Jóri ; Otto Bundschuh ; Markus Falk ; Lukas Heukamp ; Alexander Kluge ; Markus Tiemann ; Kay Christel Willborn ; Johannes Woitzik ; Frank Griesinger
Translational Lung Cancer Research [Erscheinungsort nicht ermittelbar] : [Verlag nicht ermittelbar], 2012 13(2024), 7, Seite 1794-1755 Online-Ressource
von Edgar Santos ; Juan M. Lopez-Navarro ; Marcos Alejandro Suarez-Gutierrez ; Niklas Holzwarth ; Pablo Albiña-Palmarola ; Thomas Kirchner ; Adrian Hernandez Aguilera ; Jose Antonio Fernandez-Amador ; Farzam Vazifehdan ; Johannes Woitzik ; Lena Maier-Hein ; Renán Sánchez-Porras
von Roberto Díaz-Peregrino ; Modar Kentar ; Carlos Alberto Trenado Colin ; Renán Sánchez-Porras ; Pablo Albiña-Palmarola ; Francisco L. Ramírez-Cuapio ; Daniel San-Juan ; Andreas Unterberg ; Johannes Woitzik ; Edgar Santos
ECoG recording; Mild hypothermia; power spectrum of frequency bands; Spreading depolarization; Stroke progression
Objective: Characterize the neurophysiological effects of mild hypothermia on stroke and spreading depolarizations (SDs) in gyrencephalic brains. Methods: Left middle cerebral arteries (MCAs) of six hypothermic and six normothermic pigs were permanently occluded (MCAo). Hypothermia began 1 h after MCAo and continued throughout the experiment. ECoG signals from both frontoparietal cortices were recorded. Five-minute ECoG epochs were collected 5 min before, at 5 min, 4, 8, 12, and 16 h after MCAo, and before, during, and after SDs. Power spectra were decomposed into fast (alpha, beta, and gamma) and slow (delta and theta) frequency bands. Results: In the vascular insulted hemisphere under normothermia, electrodes near the ischemic core exhibited power decay across all frequency bands at 5 min and the 4th hour after MCAo. The same pattern was registered in the two furthest electrodes at the 12th and 16th hour. When mild hypothermia was applied in the vascular insulted hemispheres, the power decay was generalized and seen even in electrodes with uncompromised blood flow. During SD analysis, hypothermia maintained increased delta and beta power during the three phases of SDs in the furthest electrode from the ischemic core, followed by the second furthest and third electrode in the beta band during preSD and postSD segments. However, in hypothermic conditions, the third electrode showed lower delta, theta, and alpha power. Conclusion: Mild hypothermia attenuates all frequency bands in the vascularly compromised hemisphere, irrespective of the cortical location. During SD formation, it preserves power spectra more significantly in electrodes further from the ischemic core.
Frontiers in neuroscience Lausanne : Frontiers Research Foundation, 2007 18(2024), Artikel-ID 1302767, Seite 1-15 Online-Ressource
von Christina M Kowoll ; Leonie Schumm ; Alexandra Gieffers ; Coline L Lemale ; Sebastian Major ; Christian Dohmen ; Gereon R. Fink ; Gerrit Brinker ; Tilmann von Pidoll ; Patrick Dömer ; Jens P. Dreier ; Nils Nicholas Hecht ; Johannes Woitzik
von Patrick Dömer ; Simeon Helgers ; Franziska Meinert ; Renán Sánchez-Porras ; Christian Mathys ; Karsten Witt ; Peter Vajkoczy ; Nils Nicholas Hecht ; Johannes Woitzik
von Nils Nicholas Hecht ; Daisy Haddad ; Konrad Neumann ; Leonie Schumm ; Nora Dengler ; Lars Wessels ; Patrick Dömer ; Simeon Helgers ; Franziska Meinert ; Sebastian Major ; Coline L. Lemale ; Jens P. Dreier ; Peter Vajkoczy ; Johannes Woitzik
