von Dagmar Krefting ; Nico T. Mutters ; Rüdiger Pryss ; Martin Sedlmayr ; Martin Boeker ; Christoph Dieterich ; Carolin Koll ; Martina Mueller ; Anna Slagman ; Dagmar Walthemath ; Antje Wulff ; Sven Zenker
von Marco Sander ; Richard Dano ; Anja Martha Bieber ; Anna Dammermann ; Steffen Fleischer ; Claudia Dinand ; Martin Müller ; Ralph Möhler ; Kristin Schultes ; Sascha Köpke ; Martin N. Dichter ; Falk Hoffmann ; Alexander M. Fassmer
von Martin Metzenmacher ; Frank Griesinger ; Horst-Dieter Hummel ; Corinna Elender ; Harald Schäfer ; Maike de Wit ; Ulrich Kaiser ; Jens Kern ; Martina Jänicke ; Lisa Spring ; Stefan Zacharias ; Anja Kaiser-Osterhues ; Annika Groth ; Annette Hipper ; Gregor Zaun ; Steffen Dörfel ; Björn Güldenzoph ; Lothar Müller ; Jens Uhlig ; Michael Thomas ; Martin Sebastian ; Wilfried E. E. Eberhardt
von Bernd Metzner ; Thomas H. Müller ; Jochen Casper ; Christoph Kimmich ; Claus-Henning Köhne ; Eduard Petershofen ; Andrea Renzelmann ; Ruth Thole ; Andreas Voß ; Martin Dreyling
von Dominik Sturm ; David Capper ; Felipe Andreiuolo ; Marco Gessi ; Christian Kölsche ; Annekathrin Reinhardt ; Philipp Sievers ; Annika K. Wefers ; Azadeh Ebrahimi ; Abigail Kora Suwala ; Gerrit H. Gielen ; Martin Sill ; Daniel Schrimpf ; Damian Stichel ; Volker Hovestadt ; Bjarne Daenekas ; Agata Rode ; Stefan Hamelmann ; A. Christopher Previti ; Natalie Jäger ; Ivo Buchhalter ; Mirjam Blattner-Johnson ; Barbara Christine Jones ; Monika Warmuth-Metz ; Brigitte Bison ; Kerstin Grund ; Christian Sutter ; Steffen Hirsch ; Nicola Dikow ; Olaf Witt ; Andreas von Deimling ; Hermann L. Müller ; Torsten Pietsch ; Felix Sahm ; Stefan Pfister ; David T. W. Jones
Cancer epidemiology; Cancer epigenetics; CNS cancer; Diagnostic markers; Paediatric cancer
The large diversity of central nervous system (CNS) tumor types in children and adolescents results in disparate patient outcomes and renders accurate diagnosis challenging. In this study, we prospectively integrated DNA methylation profiling and targeted gene panel sequencing with blinded neuropathological reference diagnostics for a population-based cohort of more than 1,200 newly diagnosed pediatric patients with CNS tumors, to assess their utility in routine neuropathology. We show that the multi-omic integration increased diagnostic accuracy in a substantial proportion of patients through annotation to a refining DNA methylation class (50%), detection of diagnostic or therapeutically relevant genetic alterations (47%) or identification of cancer predisposition syndromes (10%). Discrepant results by neuropathological WHO-based and DNA methylation-based classification (30%) were enriched in histological high-grade gliomas, implicating relevance for current clinical patient management in 5% of all patients. Follow-up (median 2.5 years) suggests improved survival for patients with histological high-grade gliomas displaying lower-grade molecular profiles. These results provide preliminary evidence of the utility of integrating multi-omics in neuropathology for pediatric neuro-oncology.
Nature medicine [New York, NY] : Springer Nature, 1995 29(2023), 4, Seite 917-926 Online-Ressource
von Juliane K. Müller ; Kira F. Ahrens ; Michael Bauer ; Bernhard T. Baune ; Stefan Borgwardt ; Jürgen Deckert ; Katharina Domschke ; Regina Ellwanger ; Andreas Fallgatter ; Thomas Frodl ; Jürgen Gallinat ; René Gottschalk ; Hans Jörgen Grabe ; Alkomiet Hasan ; Sabine Herpertz ; René Hurlemann ; Frank Jessen ; Joseph Kambeitz ; Tilo Kircher ; Johannes Kornhuber ; Klaus Lieb ; Andreas Meyer-Lindenberg ; Rainer Rupprecht ; Norbert Scherbaum ; Christiane Schlang ; Anja Schneider ; Georg Schomerus ; Andreas Thoma ; Stefan Unterecker ; Martin Walter ; Henrik Walter ; Andreas Reif ; Christine Reif-Leonhard
Zeitschrift für Evidenz, Fortbildung und Qualität im Gesundheitswesen Heidelberg : Elsevier, Urban & Fischer, 2008 171(2022), Seite 49-57 Online-Ressource
von Patrick Wagner ; Nils Strodthoff ; Patrick Wurzel ; Arturo Marban ; Sonja Scharf ; Hendrik Schäfer ; Philipp Seegerer ; Andreas Loth ; Sylvia Hartmann ; Frederick Klauschen ; Klaus-Robert Müller ; Wojciech Samek ; Martin-Leo Hansmann
