Background - Cancer immunotherapy has revolutionized melanoma treatment, but the high number of non-responders still emphasizes the need for improvement of therapy. One potential avenue for enhancing anti-tumor treatment is through the modulation of coagulation and platelet activity. Both have been found to play an important role in the tumor microenvironment, tumor growth and metastasis. Preclinical studies indicate a beneficial effect, clinical data has been inconsistent. - Methods - We examined a cohort of advanced, non-resectable melanoma patients (n = 2419) derived from the German prospective multicenter skin cancer registry ADOReg, who were treated with immune checkpoint inhibitors (ICI). The patients were classified based on whether it was documented that they received platelet aggregation inhibition (PAI) (n = 137) (acetylsalicylic acid (ASA) or clopidogrel), anticoagulation (AC) (n = 185) (direct oral anticoagulation (DOAC), phenprocoumon, heparins) at the start of ICI or no antithrombotic medication (n = 2097) at any point during ICI treatment. The study endpoints were best overall response (BOR), progression-free survival (PFS) and overall survival (OS). - Results - A significantly improved PFS was observed in patients documented to receive ASA (15.1 vs 6.4 months, HR 0.67, 95 % CI: 0.5 to 0.88, p = 0.0047) as well as in patients to receive AC (15.1 vs. 6.4 months, HR 0.7, 95 % CI: 0.53 to 0.91, p = 0.01) compared to patients for whom no antithrombotic medication was documented. Multivariate analysis of OS showed significant risk reduction in patients who received DOAC (HR 0.68, 95 % CI: 0.49 to 0.92, p = 0.0170) or phenprocoumon (HR: 0.44, 95 % CI: 0.19 to 0.85, p = 0.0301). - Conclusion - Our study indicates a positive prognostic effect of anticoagulant and antiplatelet concomitant medication in melanoma patients receiving ICI. Further studies are needed to confrim the cancer-related benefit of adding anticoagulation or platelet inhibition to ICI treatment.
European journal of cancer Amsterdam [u.a.] : Elsevier, 1992 214(2025) vom: Jan., Artikel-ID 115159, Seite 1-11
In speech audiometry, the speech-recognition threshold (SRT) is usually established by adjusting the signal-to-noise ratio (SNR) until 50% of the words or sentences are repeated correctly. However, these conditions are rarely encountered in everyday situations. Therefore, for a group of 15 young participants with normal hearing and a group of 12 older participants with hearing impairment, speech-recognition scores were determined at SRT and at four higher SNRs using several stationary and fluctuating maskers. Participants’ verbal responses were recorded, and participants were asked to self-report their listening effort on a categorical scale (self-reported listening effort, SR-LE). The responses were analyzed using an Automatic Speech Recognizer (ASR) and compared to the results of a human examiner. An intraclass correlation coefficient of r = .993 for the agreement between their corresponding speech-recognition scores was observed. As expected, speech-recognition scores increased with increasing SNR and decreased with increasing SR-LE. However, differences between speech-recognition scores for fluctuating and stationary maskers were observed as a function of SNR, but not as a function of SR-LE. The verbal response time (VRT) and the response speech rate (RSR) of the listeners’ responses were measured using an ASR. The participants with hearing impairment showed significantly lower RSRs and higher VRTs compared to the participants with normal hearing. These differences may be attributed to differences in age, hearing, or both. With increasing SR-LE, VRT increased and RSR decreased. The results show the possibility of deriving a behavioral measure, VRT, measured directly from participants’ verbal responses during speech audiometry, as a proxy for SR-LE.
Trends in hearing Thousand Oaks, Calif. : Sage, 2014 28(2024), Seite 1-20 Online-Ressource
von Matthias Lange ; Katharina Schütz ; Yannick Figura ; Tim Alexander Alten ; Matthias Kopp ; Jürgen Seidenberg ; Christian Vogelberg ; Tobias Ankermann ; Holger Köster ; Thomas Illig ; Christiane Lex ; Antje Schuster ; Marcus Panning ; Gernot Gerhard Ulrich Rohde ; Tobias Welte ; Martin Wetzke ; Gesine Hansen ; Diane Miriam Esther Renz
von Martin Wetzke ; Dominik Funken ; Matthias Lange ; Levente Bejo ; Sibylle Haid ; Joao G. Tereno Monteiro ; Katharina Schütz ; Christine Happle ; Thomas F. Schulz ; Jürgen Seidenberg ; Thomas Pietschmann ; Gesine Hansen
von Matthias Lange ; Christine Happle ; Juliane Hamel ; Michael Dördelmann ; Mathieu Bangert ; Rolf Kramer ; Frank Eberhardt ; Marcus Panning ; Axel Heep ; Gesine Hansen ; Martin Wetzke
von Gesche M. Voigt ; Dominik Thiele ; Martin Wetzke ; Jürgen Weidemann ; Patricia-Maria Parpatt ; Tobias Welte ; Jürgen Seidenberg ; Christian Vogelberg ; Holger Köster ; Gernot Gerhard Ulrich Rohde ; Christoph Härtel ; Gesine Hansen ; Matthias Kopp
DAGA (46. : 2020 : Hannover) Tagungsband, DAGA 2020 - 46. Jahrestagung für Akustik Berlin : Deutsche Gesellschaft für Akustik e.V., 2020 (2020), Seite 106-109 1 Online-Ressource
