Deutsche Gesellschaft für Ökonomische Bildung (2023 : Tübingen) Digitalisierung in der Ökonomischen Bildung Wiesbaden : Springer Fachmedien Wiesbaden, 2025 (2025), Seite 27-42 1 Online-Ressource(XIII, 319 S. 54 Abb.)
von Frank Martin Brunkhorst ; Michael Adamzik ; Hubertus Axer ; Michael Bauer ; Christian Bode ; Hans-Georg Bone ; Thorsten Brenner ; Michael Bucher ; Sascha Igor David ; Maximilian Dietrich ; Christian Eckmann ; Gunnar Elke ; Torben Esser ; Thomas Felbinger ; Christine Geffers ; Herwig Gerlach ; Beatrice Grabein ; Matthias Gründling ; Ulf Günther ; Stefan Hagel ; Andreas Hecker ; Stefan Henkel ; Babila Janusan ; Stefan John ; Achim Jörres ; Achim Kaasch ; Stefan Kluge ; Matthias Kochanek ; Agnieszka Lajca ; Gernot Marx ; Konstantin Mayer ; Patrick Meybohm ; Onnen Mörer ; Michael Oppert ; Vladimir Patchev ; Mathias Pletz ; Christian Putensen ; Tim Rahmel ; Jenny Rosendahl ; Rolf Rossaint ; Bernd Salzberger ; Michael Sander ; Stefan Schaller ; Christina Scharf-Janssen ; Felix Schmitt ; Matthias Unterberg ; Markus A. Weigand ; Arved Weimann ; Sebastian Weis ; Björn Weiß ; Alexander Wolf ; Alexander Zarbock
The articles in this volume offer an interdisciplinary analysis of the Oracles against the Nations in the Book of Jeremiah, exploring their literary, historical, and theological significance. Bringing together leading international scholars, it integrates biblical exegesis with archaeological and historical research, shedding new light on the political and cultural contexts of these prophetic texts. The book challenges both traditional views (OAN as an irrelevant appendix) as well as modern biases (OAN as Schadenfreude-literature) by demonstrating how these oracles are not mere additions but essential to the prophetic message of Jeremiah. With a strong focus on the historical rooting of the oracles, it provides fresh insights into the complex dynamics between Israel and its neighbouring nations. A key resource for scholars of biblical studies, ancient history, and theology.
Lithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and disabling mental health disorder that affects about 1% of the population worldwide. Nevertheless, lithium is not consistently effective, with only 30% of patients showing a favorable response to treatment. To provide personalized treatment options for bipolar patients, it is essential to identify prediction biomarkers such as polygenic scores. In this study, we developed a polygenic score for lithium treatment response (Li+PGS) in patients with BD. To gain further insights into lithium’s possible molecular mechanism of action, we performed a genome-wide gene-based analysis. Using polygenic score modeling, via methods incorporating Bayesian regression and continuous shrinkage priors, Li+PGS was developed in the International Consortium of Lithium Genetics cohort (ConLi+Gen: N = 2367) and replicated in the combined PsyCourse (N = 89) and BipoLife (N = 102) studies. The associations of Li+PGS and lithium treatment response — defined in a continuous ALDA scale and a categorical outcome (good response vs. poor response) were tested using regression models, each adjusted for the covariates: age, sex, and the first four genetic principal components. Statistical significance was determined at P < 0.05. Li+PGS was positively associated with lithium treatment response in the ConLi+Gen cohort, in both the categorical (P = 9.8 × 10−12, R2 = 1.9%) and continuous (P = 6.4 × 10−9, R2 = 2.6%) outcomes. Compared to bipolar patients in the 1st decile of the risk distribution, individuals in the 10th decile had 3.47-fold (95%CI: 2.22-5.47) higher odds of responding favorably to lithium. The results were replicated in the independent cohorts for the categorical treatment outcome (P = 3.9 × 10−4, R2 = 0.9%), but not for the continuous outcome (P = 0.13). Gene-based analyses revealed 36 candidate genes that are enriched in biological pathways controlled by glutamate and acetylcholine. Li+PGS may be useful in the development of pharmacogenomic testing strategies by enabling a classification of bipolar patients according to their response to treatment.
Bärbel Boldt; Werner Boldt; Dirk Grathoff; Gerhard Kraiker; Frank D Wagner; Gunther Nickel
Reinbek bei Hamburg: Rowohlt
255 Seiten.
Nebent.: Ossietzky-Lesebuch
Ossietzky,Carl von; Weimarer Republik; Weimar Republic; Deutschland Geschichte 1918-1933 Quelle; Weimarer Republik Geschichte Quelle; QuelleWeimarer RepublikGeschichteDeutschlandGeschichte 1918-1933DeutscheDeutsches Sprachgebiet03.10.1990-1918-1933
