von Sophie-Kathrin Greiner ; María Dech Pons ; Ayimnisagul Ablimit ; Elisa Brauße ; Kristina Adorjan ; Monika Budde ; Maria Heilbronner ; Urs Heilbronner ; Janos L. Kalman ; Alba Navarro-Flores ; Mojtaba Oraki Kohshour ; Daniela Reich-Erkelenz ; Eva C. Schulte ; Thomas Vogl ; Till Andlauer ; Ion-George Anghelescu ; Volker Arolt ; Bernhardt T. Baune ; Udo Dannlowski ; Franziska Degenhardt ; Detlef E. Dietrich ; Andreas J. Fallgatter ; Christian Figge ; Andreas Forstner ; Markus Jäger ; Georg Juckel ; Carsten Konrad ; Markus M. Nöthen ; Fabian U. Lang ; Jens Reimer ; Eva Z. Reinighaus ; Marcella Rietschel ; Max Schmauß ; Andrea Schmitt ; Simon Senner ; Carsten Spitzer ; Jens Wiltfang ; Stephanie Witt ; Jörg Zimmermann ; Alkomiet Hasan ; Peter Falkai ; Thomas G. Schulze ; Sergi Papiol ; Fanny Senner
Online verfügbar: 13. Mai 2025, Artikelversion: 26. Mai 2025 ; Gesehen am 18.08.2025
Adverse childhood experiences; Affective disorders; Global functioning; Psychotic disorders; Quality of life
Adverse childhood experiences (ACE) contribute significantly to mental disorders. While existing research has primarily focused on specific diagnostic categories, a comprehensive understanding of how childhood trauma interacts with biological factors, symptom severity and functioning requires a broader perspective. Therefore, this study adopted a cross-diagnostic approach to examine the impact of ACE on quality of life (QoL), psychosocial functioning, and symptom burden by analyzing data from the PsyCourse Study, a longitudinal, multicenter research project conducted in Germany and Austria. We used multivariate linear regression models and cluster analysis to evaluate data from 725 participants with affective and psychotic disorders and healthy controls who completed the self-assessed Childhood Trauma Screener (CTS) during the course of the study. The results showed that across diagnoses, QoL was significantly impacted by ACE, particularly emotional neglect. An ablation study revealed that 2.3 % to 6.2 % of the variability in QoL domains could be attributed to ACE. Across diagnoses, symptoms of depression were significantly associated with ACE, especially emotional abuse, but psychotic and manic symptoms were not. Polygenic risk scores (PRS) did not emerge as significant predictors for any examined outcomes. Cluster analysis revealed distinct symptom profiles: Averaged over time, patients with less trauma exposure were rather in the subclinical than in the clinically ill clusters. We conclude that the pervasive influence of ACE on disease severity should be considered when evaluating and treating patients with affective and psychotic disorders.
Psychiatry research Amsterdam [u.a.] : Elsevier Science, 1979 350(2025) vom: Aug., Artikel-ID 116536, Seite 1-10 Online-Ressource
Background Employment and relationship are crucial for social integration. However, individuals with major psychiatric disorders often face challenges in these domains. Aims We investigated employment and relationship status changes among patients across the affective and psychotic spectrum – in comparison with healthy controls, examining whether diagnostic groups or functional levels influence these transitions. Method The sample from the longitudinal multicentric PsyCourse Study comprised 1260 patients with affective and psychotic spectrum disorders and 441 controls (mean age ± s.d., 39.91 ± 12.65 years; 48.9% female). Multistate models (Markov) were used to analyse transitions in employment and relationship status, focusing on transition intensities. Analyses contained multiple multistate models adjusted for age, gender, job or partner, diagnostic group and Global Assessment of Functioning (GAF) in different combinations to analyse the impact of the covariates on the hazard ratio of changing employment or relationship status. Results The clinical group had a higher hazard ratio of losing partner (hazard ratio 1.46, P < 0.001) and job (hazard ratio 4.18, P < 0.001) than the control group (corrected for age/gender). Compared with controls, clinical groups had a higher hazard of losing partner (affective group, hazard ratio 2.69, P = 0.003; psychotic group, hazard ratio 3.06, P = 0.001) and job (affective group, hazard ratio 3.43, P < 0.001; psychotic group, hazard ratio 4.11, P < 0.001). Adjusting for GAF, the hazard ratio of losing partner and job decreased in both clinical groups compared with controls. Conclusion Patients face an increased hazard of job loss and relationship dissolution compared with healthy controls, and this is partially conditioned by the diagnosis and functional level. These findings underscore a high demand for destigmatisation and support for individuals in managing their functional limitations.
BJPsych Open Cambridge : Cambridge University Press, 2015 11(2024), 1, Artikel-ID e11, Seite 1-10 Online-Ressource
